(13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine
5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]benzo-1,3-dioxolo[5,6-a]quinolizine
CAS: 522-97-4
Molecular Formula: C20H21NO4
(13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine - Names and Identifiers
| Name | 5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]benzo-1,3-dioxolo[5,6-a]quinolizine |
| Synonyms | canadine Nsc94918 l-Canadine l-Xanthopuccine l-Tetrahydroberberine Berberine, tetrahydro- Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)- 5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]benzo-1,3-dioxolo[5,6-a]quinolizine 6H-Benzo[G]-1,3-benzodioxolo[5,6-A]quinolizine, 5,8,13,13A-tetrahydro-9,10-dimethoxy- (13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine |
| CAS | 522-97-4 |
| EINECS | 208-338-2 |
| InChI | InChI=1/C20H21NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,8-9,16H,5-7,10-11H2,1-2H3 |
(13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine - Physico-chemical Properties
| Molecular Formula | C20H21NO4 |
| Molar Mass | 339.39 |
| Density | 1.33±0.1 g/cm3(Predicted) |
| Melting Point | 166.5 °C |
| Boling Point | 476.1±45.0 °C(Predicted) |
| Solubility | Soluble in hot water, hot ethanol, insoluble in acetone, chloroform |
| Appearance | Pale yellow needle crystal |
| Color | yellow |
| pKa | 6.53±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00067284 |
| Physical and Chemical Properties | Light yellow crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Phellodendron, Corydalis tuber, Corydalis. |
(13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Toxicity | LD50 in mice (mg/kg): 940 orally; 790 s.c.; 100 i.v. (Sadritdinov, Sultanov) |
(13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine - Reference
| Reference Show more | 1. Fang Xingyue, Liu Qibing, Yang Xiao et al. Effect of tetrahydroberberine on vascular endothelial cell injury [J]. Journal of Hainan Medical College 2020(15):1146-1151. 2. Antrum Zenghua, du Lianping. Simultaneous determination of six components in compound yuanhu Zhitong tablets by HPLC [J]. Chinese patent medicine 2017 39(02):312-315. 3. Feng Xin, Zhao Wenjun, Hou Ting, et al. Determination of 14 components in ermiao powder extract by UPLC-MS/MS [J]. Chinese Journal of Experimental prescriptions, 2017, 023(021):79-85. 4. [IF = 5.81] Xiao Xiaofei et al."The Anti-Diaria Activity of the Non-toxic Dihuang Powder in Mice." Front Pharmacol. 2018 Sep;0:1037 5. [IF = 4.411] Jinjun Shan et al."Liquid Chromatography Coupled with Linear Ion Trap Hybrid OrbitrapMass Spectrometry for Determination of Alkaloids in Sinomeniumacutum."Molecules. 2018 Jul;23(7):1634 6. [IF=3.004] Kai Zhang et al."Untargeted metabolomics reveals the synergistic mechanisms of Yuanhu Zhitong oral liquid in the treatment of primary dysmenorrhea."J Chromatogr B. 2021 Feb;1165:122523 |
(13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine - Reference Information
| Target | Value |
| D2 receptor () | 6.08(pKi) |
| 5-HT1A () | 5.38(pKi) |
| use | tetrahydroberberine has antiarrhythmic effect. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: sedation and analgesia. |
Last Update：2024-04-09 21:11:58
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Product Name: Canadine Visit Supplier Webpage Request for quotationCAS: 522-97-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Tetrahydroberberine,THB Visit Supplier Webpage Request for quotationCAS: 522-97-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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(13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine
1346601-70-4
1346601-70-4